With the exception of the impact of the recent aforementioned acquisitions, the adjustments excluded from our non-GAAP financial measures are consistent with those excluded from our operating segments' measures of net sales and profit or loss. The U.S. is by far the most important region for Boston Scientific with approximately 6.1 billion U.S. dollars in revenue during 2019. For 2018 as a whole, Boston Scientific announced updated revenue guidance of $9.75 billion to $9.9 billion, up from previous guidance of $9.65 billion to 9.8 billion. Between 2015 and 2017, the company recorded litigation-related charges of nearly $2.2 billion, much of which was for mesh claims, securities filings say. It now sees adjusted earnings of $1.37 to $1.41 per share for 2018, compared with its previous guidance of $1.35 to $1.39.Boston Scientific Chief Executive Mike Mahoney told investors early Wednesday that the company was "excited about 2018 and our plans to build upon our global momentum and drive sustainable long-term growth and differentiated financial performance.
Management's Discussion and Analysis of Financial Condition and Results of Operations in our most recent Annual Report filed on Form 10-K with the Securities and Exchange Commission for an explanation of each of these adjustments and the reasons for excluding each item. The GAAP financial measure most directly comparable to operational net sales and organic net sales is net sales on a GAAP basis.Boston Scientific is dedicated to transforming lives through innovative medical solutions that improve the health of patients around the world.Reconciliations of each of these non-GAAP financial measures to the corresponding GAAP financial measure are included in the accompanying schedules.The GAAP financial measures most directly comparable to adjusted net income and adjusted net income per share are GAAP net income and GAAP net income per share.Fueling the next generation of life science professionalsSOURCE Boston Scientific Corporation©2019 Boston Scientific Corporation or its affiliates. View the latest BSX financial statements, income statements and financial ratios. The GAAP financial measure most directly comparable to operational net sales and organic net sales is net sales on a GAAP basis.Explore Educare, our globally recognized education programTo calculate adjusted net income (earnings) and adjusted net income (earnings) per share we exclude certain charges (credits) from GAAP net income, including amortization expense, intangible asset impairment charges, acquisition-related net charges (credits), restructuring and restructuring-related net charges (credits), litigation-related net charges (credits), certain investment impairment charges and certain discrete tax items.